Issues with Detecting ANY phone

Im constantly getting errors when trying to connect phones through the octopus box. Initially, when I had installed the software and hooked up the box, everything was working completely fine. Until yesterday, it’s telling me that No diagnostics ports found! and Port is busy. and Phone was not found on the selected port! I don’t understand what has changed since now and then. Any help would be greatly appreciated. I’m also using the Samsung Galaxy S5 (SM-G900T).